照片
张天富，副教授。
2017-2021
香港科技大学化学博士（导师：唐本忠院士），
2021-2022
香港心
脑血管健康工程中心博士后（中心主任：张元亭院士，导师：
Bee Luan Khoo
教授），
2022-2023
香港
心脑血管健康工程中心担任研究助理科学家。主要研究致力于设计并开发一系列具有聚集诱导发光
(AIE)性质的有机荧光材料，用于重大疾病(癌症、阿尔兹海默症)的体外/体内的多模态光诊疗。目前共
发表
SCI
论文
15
篇
(IF
＞
10)
，其中以一作
/
共一发表
J. Am. Chem. Soc., Angew. Chem., Adv. Funct. Mater.,
Nano Today, ACS Nano, Biomaterials
等论文
10
篇。相关成果已申请美国专利
2
项
,
中国专利
1
项。多
次受邀参加国际、国内会议并获最佳报告奖项，获得 2021 年和 2022 年心脑血管工程领域杰出学者奖。
1. Tianfu Zhang#, Xiaoyu Chen#, Congmin Yuan, Xiaobin Pang, Ping Shangguan, Lulu Han, Yisheng
Liu, Jianwei Sun, Jacky W. Y. Lam, Jiefei Wang,* Bingyang Shi,* Ben Zhong Tang* Design of NIR AIEgens
for In Vivo Theranostics of Alzheimer’s Disease: BBB Penetration, Fibrosis Inhibition and β-Amyloid
Disassembly. Angew. Chem. Int. Ed. 2023, 62, e202211550.
2. Tianfu Zhang#, Zeming Liu#, Wenxue Tang#, Meng Lyu, Jacky Wing Yip Lam, Qinqin Huang,*
Ben Zhong Tang* Mitochondria-Targeting Type I AIE Photosensitizer Combined with H2S Therapy:
Uninterrupted Hydroxyl Radical Generation for Enhancing Tumor Therapy. Nano Today 2022. 46, 101620.
3. Tianfu Zhang#, Jianyu Zhang#, Fu-Bing Wang#, Hui Cao, Daoming Zhu, Xiaoyu Chen, Changhuo
Xu, Xueqin Yang, Wenbin Huang, Zhaoyu Wang, Jiefei Wang, Zikai He, Zheng Zheng,* Jacky Wing Yip
Lam,* and Ben Zhong Tang* Mitochondria-Targeting Phototheranostics by Aggregation-Induced NIR-II
Emission Luminogens: Modulating Intramolecular Motion by Electron Acceptor Engineering for
Multi-Modal Synergistic Therapy. Adv. Funct. Mater. 2022, 2110526.
4. Tianfu Zhang#,* Yanlin Deng#, Sylvia Yang Liu, Song Lin Chua,* Ben Zhong Tang,* Bee Luan
Khoo* Bacterial Targeted Photosensitizers with Aggregation-induced Emission Property Synergistically
Promote Chemotherapy for the Treatment of Inflammatory Cancer. Chem. Eng. J. 2022, 447, 137579.
5. Tianfu Zhang#, Yuanyuan Li#, Zheng Zheng, Ruquan Ye, Yiru Zhang, Ryan T.K. Kwok, Jacky W. Y.
Lam and Ben Zhong Tang*. In Situ Monitoring Apoptosis Process by a Self-Reporting Photosensitizer. J.
Am. Chem. Soc. 2019, 141, 5612-5616. (One of the most highly cited papers in JACS 2018-2019)
6. Shipeng Ning,# Tianfu Zhang#, Meng Lyu, Jacky W. Y. Lam, Daoming Zhu,* Qinqin Huang,* Ben
Zhong Tang* A type I AIE photosensitiser-loaded biomimetic nanosystem allowing precise depletion of
cancer stem cells and prevention of cancer recurrence after radiotherapy. Biomaterials 2023, 295, 122034.
7. Daoming Zhu#, Tianfu Zhang#, Yang Li, Chunyu Huang, Meng Suo, Ligang Xia, Youhua Xu,*
Guoxin Li,* Ben Zhong Tang* Tumor-derived exosomes co-delivering aggregation-induced emission
luminogens and proton pump inhibitors for tumor glutamine starvation therapy and enhanced type-I
photodynamic therapy. Biomaterials 2022, 283, 121462.
8. Chunyu Huang#, Tianfu Zhang#, Yang Li#, Meng Lyu, Meng Suo, Ligang Xia, Lingrong Liu,* Ben
Zhong Tang*, Qiqing Zhang* Type-I AIE photosensitizer triggered cascade catalysis system for tumor
targeted therapy and postoperative recurrence suppression. Chem. Eng. J. 2022, 446, 136381.
9. Wei He#, Tianfu Zhang#, Haotian Bai, Ryan T. K. Kwok,* Jacky W. Y. Lam, Ben Zhong Tang*
Recent Advances in Aggregation-Induced Emission Materials and Their Biomedical and Healthcare
Applications. Adv. Healthcare Mater. 2021, 2101055.
10. Zheng Zheng#, Tianfu Zhang#, Haixiang Liu#, Yuncong Chen, Ryan T.K. Kwok, Chao Ma,
Pengfei Zhang, Herman H. Y. Sung, Ian D. Williams, Jacky W.Y. Lam, Kam Sing Wong, Ben Zhong Tang*.
Bright Near-Infrared Aggregation-Induced Emission Luminogens with Strong Two-Photon Absorption,
Excellent Organelle Specificity, and Efficient Photodynamic Therapy Potential. ACS Nano 2018, 12,
8145-8159.
1. Bee Luan Khoo, Tianfu Zhang. A Composition And A Method For Diagnosing And Treating
Bacterial Infection. (U.S. Patent, filled 11/2021, No. 17/536,193).
2. Ben Zhong Tang, Jacky W. Y. Lam, Tianfu Zhang. Amphiphilic Probes with Aggregation-Induced
Emission Characteristics for In Vivo Detection of beta-Amyloid Deposits and In Situ Inhibition of
beta-amyloid Aggregation. (U.S. Patent, filled 11/2021, 63274945).
姓名
张天富
性别
男
电话
13268166414
邮箱
zhangtf@gzhmu.edu.cn
南山学者类别
全职引进
南山学者层次
后备人才
所在二级单位
生工学院
学科分类
生物医学工程
科研领域
聚集诱导发光、聚集体光学材料、荧光成像、癌症光诊疗、
阿尔兹海默症诊疗
2013 年-2017 年，本科就读于中山大学与香港理工大学化学专业
2017 年-2021 年，博士就读于香港科技大学化学专业
2021-2022 年，就职于香港心脑血管健康工程，博士后
2021-2022 年，就职于香港心脑血管健康工程，研究助理科学家（
research associate scientist
）
个人简介
工作经历
期刊论文
教育经历
专 利
1.获得 2021 及 2022 年 Outstanding Scholars in Cardiovascular Engineering Award。
1.
广州医科大学“南山学者”高层次引进人才项目启动经费。
科研项目
科研奖项
