本人多年从事有关天然免疫在宿主防御和炎性疾病中分子机制方面的研究工作

,

特别是在核酸免

疫识别方面曾做出了开创性的贡献。至今，已在在国际知名刊物上共发表近

30

篇论文，其中第一和通

讯作者文章 14 篇 （其中 3 篇被 Faculty of 1000 收录），专利 1 项。论文总引用次数 4200 次 （单篇

平均引用>100 次，Google Scholar）。特别值得一提是这两项工作：①DNA 天然免疫识别受体 cGAS

和其产物第二信使

2

‘

1. She L, Barrera GD, Yan L, Alanazi HH, Brooks EG, Dube PH, Sun Y, Zan H, Chupp DP, Zhang N,

Zhang X, Liu Y,* Li XD*. STING activation in alveolar macrophages and group 2 innate lymphoid cells

suppresses IL-33-driven type 2 immunopathology. JCI Insight. 2021 Feb 8;6(3):e143509.

doi:10.1172/jci.insight.143509. PMID:33400692; PMCID: PMC7934858.

2. Guo L, Lu X, Liu X, Li P, Wu J, Xing F, Peng H, Xiao X, Shi M, Liu Z, Li XD*, Guo D.*

Meta-Transcriptomic Analysis Reveals the Virome and Viral Genomic Evolution of Medically Important

4. Alanazi HH, She L, Li XD*. Identification and Characterization of Immunogenic RNA Species in

HDM Allergens that Modulate Eosinophilic Lung Inflammation. J Vis Exp. 2020 May 30;(159). doi:

10.3791/61183. PMID: 32538919.

5. She L, Alanazi HH, Yan L, Zou Y, Sun Y, Dube PH, Brooks EG, Barrera GD, Lai Z, Chen Y, Liu

Y, Zhang X, Li XD*. Immune Sensing of Aeroallergen-Associated Double-Stranded RNA Triggers an IFN

Response and Modulates Type 2 Lung Inflammation. J Immunol November 1, 2019, 203 (9) 2520-2531;

DOI:https://doi.org/10.4049/jimmunol.1900720. # Featured article

6. Xiao-Dong Li*, Jaxi Wu*, Daxing Gao, Hua Wang, Lijun Sun and Zhijian J. Chen. (2013) Pivotal

roles of cGAS-cGAMP signaling in antiviral defense and immune adjuvant effects.Science, 341:1390-1394.

(*equal contribution)

姓名

李晓东

性别