2018
年至今，就职于广州医科大学，副教授
1. Huang B, Hao M, Li C, et al. Acetyltanshinone iia reduces the synthesis of cell cycle-related proteins
by degrading p70s6k and subsequently inhibits drug-resistant lung cancer cell growth [J]. Pharmacol Res,
2022,179: 106209.
2. Zou Z C, Fu J J, Dang Y Y, et al. Pinocembrin-7-methylether protects sh-sy5y cells against
6-hydroxydopamine-induced neurotoxicity via modulating nrf2 induction through akt and erk pathways [J].
Neurotox Res, 2021,39(4): 1323-1337.
3. Dang Y Y, Luo H, Li Y M, et al. Curcumin prevents as(3+)-induced carcinogenesis through
regulation of gsk3beta/nrf2 [J]. Chin Med, 2021,16(1): 116.
4. Zhuo J, Chen B, Sun C, et al. Patchouli alcohol protects against chronic unpredictable mild
stress-induced depressant-like behavior through inhibiting excessive autophagy via activation of mtor
signaling pathway [J]. Biomed Pharmacother, 2020,127: 110115.
5. Li C W, Deng M Z, Gao Z J, et al. Effects of compound k, a metabolite of ginsenosides, on memory
and cognitive dysfunction in db/db mice involve the inhibition of er stress and the nlrp3 inflammasome
pathway [J]. Food Funct, 2020,11(5): 4416-4427.
6. Wu X, Tang B, Liao X, et al. Suppressive effects of the supercritical-carbon dioxide fluid extract of
chrysanthemum indicum on chronic unpredictable mild stress-induced depressive-like behavior in mice [J].
Food Funct, 2019,10(2): 1212-1224.
7. Li C, Bian Y, Feng Y, et al. Neuroprotective effects of bhdpc, a novel neuroprotectant, on
experimental stroke by modulating microglia polarization [J]. ACS Chem Neurosci, 2019,10(5): 2434-2449.
8. Li C, Zhang C, Zhou H, et al. Inhibitory effects of betulinic acid on lps-induced neuroinflammation
involve m2 microglial polarization via camkkbeta-dependent ampk activation [J]. Front Mol Neurosci,
2018,11: 98.
9. Li C, Zhang C, Zhou H, et al. Inhibitory effects of betulinic acid on lps-induced neuroinflammation
involve m2 microglial polarization via camkkbeta-dependent ampk activation [J]. Front Mol Neurosci,
2018,11: 98.
10. Li C, Tang B, Feng Y, et al. Pinostrobin exerts neuroprotective actions in neurotoxin-induced
parkinson's disease models through nrf2 induction [J]. J Agric Food Chem, 2018,66(31): 8307-8318.
代表性成果：
1.
基于“肠道菌群
-
短链脂肪酸”轴研究广藿香促进小胶质细胞
M2
表型极化抗抑郁的药效物质
和作用机制，国家自然科学基金委员会项目，
2022.01-2024.12
，在研，主持，
30
万。
2. 基于“肠道菌群-短链脂肪酸-小胶质细胞表型极化”轴研究南药广藿香抗抑郁症的作用及机制，
广东省基础与应用基础研究项目，2020.09-2023.09，在研，主持，10 万。
3. 神经保护剂 BHDPC 对脑卒中后抑郁小鼠海马神经重塑的作用机制研究，广州市科技计划项目
项目，2021.04-2023.03，在研，主持， 5 万。
团队前期基于“芳香化浊、行气化湿和醒脾开郁”和“脑病肠治”的理论基础治疗抑郁症，对多
种芳香化湿类中药及其活性成分抗抑郁症的作用活性进行筛选评价。发现广藿香等药物和经典复方活
性部位具有改善抑郁动物的病理行为。同时，从肠道菌群调控和小胶质细胞表型的相关通路阐述药物
的相关作用机制。目前，已完成相关研究发表在
Food Funct
，
Biomed Pharmacother
，
ACS Chem
Neurosci
，
Front Mol Neurosci
，
J Agric Food Chem
，
Pharmacol Res
和
Redox Biol
等杂志。
姓名
李楚文
性别
男
电话
13724050658
邮箱
lichuwen@gzhmu.edu.cn
南山学者类别
全职引进
南山学者层次
后备人才
所在二级单位
药学院
学科分类
药学
科研领域
抑郁症、卒中后抑郁、小胶质细胞、肠道菌群
工作经历
期刊论文
科研项目
团队介绍
教育经历