徐益鸣,教授,博士生导师,广东省杰出青年医学人才。主要从事重塑性血管疾病代谢机制的研
究,以期寻找代谢性靶点。相关研究成果以一作或通讯发表于
Nat Commun, EMBO Mol Med, ATVB,
cardiovascular research, British Journal of Pharmacology, Pharmacological Research 和 APS 等刊物。曾获
得了美国心血管领域青年科学奖;ATVB 年会青年研究奖;AHA 年会 ATVB 委员会青年研究奖;海
峡两岸心血管科学研讨会青年优秀论文二等奖和广东省生理学会中青年人才奖等学术奖项。担任
Circulation, European Heart Journal, American Journal of Physiology 系列和 Atherosclerosis 等杂志审稿人,
《中国动脉硬化杂志》青年编委和广东省心血管药理专业委员会常委等学术职位。
1.Shuai Guo, Litao Wang, et al. A Metabolic Basis for Endothelial NLRP3 Inflammasome in
Atherosclerosis. Cardiovascular Research Accepted (末位通讯)
2.Litao Wang, Shuai Guo, et al. Glycolysis Promotes Angiotensin II – Induced Aortic Remodeling
through Regulating Endothelial-to-Mesenchymal Transition via the Co-Repressor C-Terminal Binding
Protein-1. Hypertension Accepted (
末位通讯
)
3.Kaixiang Cao, Tiejun Zhang, et al. Glycolysis and de novo fatty acid synthesis cooperatively regulate
pathological vascular smooth muscle cell phenotypic switching and neointimal hyperplasia. The Journal of
Pathology. 2023 Apr;259(4):388-401 (末位通讯)
4.Shuai Guo, Anqi Li, Xiaodong Fu, et al. Gene-dosage effect of Pfkfb3 on monocyte/macrophage
biology in atherosclerosis. British Journal of Pharmacology 2022 Nov;179(21):4974-4991 (末位通讯)
5.Jingwei Yan, Anqi Li, Xianglin Chen, et al. Glycolysis inhibition ameliorates brain injury after
ischemic stroke by promoting the function of myeloid-derived suppressor cells. Pharmacol Res. 2022 Apr
6;179:106208 (末位通讯)
6.Li-tao Wang, Peng-cheng He, et al. Caffeine promotes angiogenesis through modulating endothelial
mitochondrial dynamics. Acta Pharmacologica Sinica 2021 0, 1–13 (共同通讯)
7.Yong Wang, Yiming Xu, Siyuan Yan, et al. Adenosine kinase is critical for neointima formation after
vascular injury by inducing aberrant DNA hypermethylation. Cardiovascular Research 2021 Feb 1; 117(2):
561
–
575 (
共一作兼共同通讯
)
8.Yiming Xu, Yong Wang, Siyuan Yan, et al. Regulation of endothelial intracellular adenosine via
adenosine kinase epigenetically modulates vascular inflammation. Nature Communications. 2017 Oct
16;8(1):943 (
一作兼共同通讯
)
9.Yiming Xu, Yong Wang, Siyuan Yan, et al. Intracellular adenosine alters epigenetic programming in
endothelial cells to promote angiogenesis. Embo Molecular Medicine. 2017 Sep;9(9):1263-1278 (一作兼共
同通讯)
10.Yiming Xu, Xiaofei an, Xin Guo, et al. Endothelial 6-phosphofructo-2-kinase (PFKFB3) plays a
critical role in angiogenesis. Arteriosclerosis, Thrombosis and Vascular Biology. 2014, 34(6):1231-9 (一作)
代表性成果: