长期从事营养与心血管代谢疾病的分子流行病学及机制研究,通过整合高通量多组学检测技术、
体内外基因编辑技术、分子生物学技术等研究策略,从人群、动物、细胞多角度多层面阐释心血管代
谢疾病的发病机制,发现新型膳食生物标志物并寻找早期营养防治靶点。系列研究工作发现:生物活
性维生素 D 与冠心病患者的死亡风险独立相关,是冠心病预后良好的生物标志物;肝脏分泌多肽
Adropin 可缓解非酒精性脂肪性肝炎中的肝脏损伤,其血清水平与疾病进展显著相关;色氨酸肠道菌
群代谢物吲哚丙酸与动脉粥样硬化性心血管疾病的风险显著相关,是心血管疾病发生发展潜在的生物
标志物。研究成果作为封面论文和同刊评述论文发表于多个领域顶级期刊,为预防或改善心血管代谢
疾病提供了新的潜在干预靶点。
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