秦燕博士，广州医科大学生物医学工程学院南山学者特聘教授，博导。干细胞及转化国家重点研

发计划-首席科学家、国家优秀青年基金获得者。主要从事核糖体结构功能与疾病的发生、发展机制研

究。致力于研究（胚胎、成体、生殖）干细胞和肿瘤干细胞的蛋白翻译调控研究，特别对（慢性）肺

病的发生、恶化以及转移过程中的诊断、治疗提出新方案。发现核糖体的

"

倒退

"

（

Qin et al., Cell, 2006

及其诱导因子 EF4 （Qin*, Nature Structural & Molecular Biology, 2008, 2012, 2014, 2016a,b）在人类肿

参与骨干），自然科学基金委重点项目、优青、面上项目（负责人）、中国科学院重点项目（负责人、

参与骨干）、先导项目（子课题负责人）等。

1. Na Zhang, Zunling Zhao, Yin Zhao, Lei Yang, Yanhong Xue, Yun Feng, Jianjun Luo, Runsheng Chen,

Wei Wei & Yan Qin*(2023). TGF-Beta changes cyto/mito-ribosome balance to target respiratory chain

complex V biogenesis in pulmonary fibrosis therapy. Signal Transduction and Targeted Therapy.

https://www.nature.com/articles/s41392-023-01370-2 (IF 39.3)

2. Li H, Huo Y, He X, Yao L, Zhang H, Cui Y, Xiao H, Xie W, Zhang D, Wang Y, Zhang S, Tu H, Cheng

Y, Guo Y, Cao X, Zhu Y, Jiang T, Guo X*,Qin Y* & Sha J*(2022). A male germ-cell-specific ribosome

controls male fertility. Nature. https://doi.org/10.1038/s41586-022-05508-0

IF 64.8

Ribosomes as organizer and performer. Science Bulletin. https://doi.org/10.1016/j.scib.2022.07.023 (IF 18.9)

5. Gao Y, Bai X, Zhang D, Han C,Yuan J, Liu W, Cao X, Chen Z, Shangguan F, Zhu Z, Gao F and Qin

Y* (2016) (*corresponding author). Mammalian elongation factor 4 regulates mitochondrial translation

essential for spermatogenesis. Nat Struct Mol Biol. https://www.nature.com/articles/nsmb.3206（IF 18.4）

6. Zhang D, Kaige Y, Liu G, Song G, Luo J, Shi Y, Cheng E, Wu S, Jiang T, Lou Z, Gao N* and Qin Y*

(2016) (*corresponding author). EF4 disengages the peptidyl-tRNA CCA end and facilitates

back-translocation on the 70S ribosome. Nat Struct Mol Biol. https://www.nature.com/articles/nsmb（IF 18.4）

7. Liu G, Zhang D, Song G, Li Z, Zhang D, Lyv Z, Aachenbach J, Dong J, Gong W, Zhao X, Nierhaus K

H and Qin Y* (2014) (*corresponding author). EF-G catalyzes tRNA translocation by disrupting interactions

between decoding center and codon-anticodon duplex. Nat Struct Mol Biol.

(*corresponding author). A conserved proline switch on the ribosome facilitates the recruitment and binding

of trGTPases. Nat. Struct. Mol. Biol. https://www.nature.com/articles/nsmb（IF 18.4）

10. Qin Y, Polacek N, Vesper O, Staub E, Einfeldt E, Wilson DN, Nierhaus KH (2006). The highly

conserved lepa is a ribosomal elongation factor that back-translocates the ribosome. Cell.

https://doi.org/10.1016/j.cell.2006.09.037

性别

女

邮箱

qiny@ibp.ac.cn