广州医科大学生命科学学院，教授，博士/硕士研究生导师，博士后合作导师，“南山学者”优秀

人才。实验室前期工作首创 AI 辅助的蛋白聚类方法，鉴定到 58 个编辑特性不同的新型脱氨酶，分别

解决了农业领域大豆碱基编辑效率低下和医疗领域碱基编辑工具难以被单个腺相关病毒颗粒递送两个

重大的应用难题。这些脱氨酶均已开发为适用于不同应用场景的、具有我国自主知识产权的碱基编辑

新工具（Huang et al.,Cell,2023）。

实验室后期将围绕多种基因编辑新工具进行大数据挖掘，并进行理性突变和改造，以应用需求为

导向，优化编辑工具，实现对疾病模型的创制以及致病位点的精准编辑。

1. Huang, J.#, Lin, Q.#, Fei, H.#, He, Z.#, Xu, H., Li, Y., Qu, K., Han, P., Gao, Q., Li, B., Liu, G.,

Zhang, L., Hu, J., Zhang, R., Zuo, E., Luo, Y., Ran, Y., Qiu, J.L., Zhao, K.T.*, and Gao, C.* (2023).

Discovery of deaminase functions by structure-based protein clustering. Cell 186, 3182-3195. (Highlighted

by Trends in Plant Science; Selected by F1000Prime)

2. Huang, J.#, Dong, J.*, & Qu, L. J.* (2021). From birth to function: Male gametophyte development

in flowering plants. Curr. Opin. Plant Biol. 63, 102118.

3. Valliyodan, B.#, Qiu, D.#, Patil, G.#, Zeng, P.#, Huang, J.#, Dai, L.#, Chen, C., Li, Y., Joshi, T.,

Song, L., Vuong, T. D., Musket, T. A., Xu, D., Shannon, J. G., Cheng, S., Liu, X.*, & Nguyen, H. T.*

(2016). Landscape of genomic diversity and trait discovery in soybean. Sci. Rep. 6, 23598.

4. Shi, Y.#, Huang, J., Sun, T., Wang, X., Zhu, C., Ai, Y., and Gu, H.* (2017). The precise regulation of

different COR genes by individual CBF transcription factors in Arabidopsis thaliana. J. Integr. Plant Biol.

59, 118

–

133.

5. Sun, Y.#, Huang, J., Zhong, S., Gu, H., He, S.*, and Qu, L.-J.* (2018). Novel DYW-type

pentatricopeptide repeat (PPR) protein BLX controls mitochondrial RNA editing and splicing essential for

early seed development of Arabidopsis. J. Genet. Genomics 45, 155

–

168.

6. Iorizzo, M.#, Ellison, S., Senalik, D., Zeng, P., Satapoomin, P., Huang, J., Bowman, M., Iovene, M.,

Sanseverino, W., Cavagnaro, P., Yildiz, M., Macko-Podgórni, A., Moranska, E., Grzebelus, E., Grzebelus,

D., Ashrafi, H., Zheng, Z., Cheng, S., Spooner, D., Van Deynze, A., and Simon, P.* (2016). A high-quality

carrot genome assembly provides new insights into carotenoid accumulation and asterid genome evolution.

Nat. Genet. 48, 657-666.

7. Zhang, J.#, Huang, Q.#, Zhong, S.#, Bleckmann, A., Huang, J., Guo, X., Lin, Q., Gu, H., Dong, J.,

Dresselhaus, T., and Qu, L.-J.* (2017). Sperm cells are passive cargo of the pollen tube in plant fertilization.

Nat. Plants 3, 17079.

8. Zhong, S.#, Liu, M.#, Wang, Z.#, Huang, Q., Hou, S., Xu, Y. C., Ge, Z., Song, Z., Huang, J., Qiu, X.,

Shi, Y., Xiao, J., Liu, P., Guo, Y. L., Dong, J., Dresselhaus, T., Gu, H., and Qu, L.-J.* (2019). Cysteine-rich

peptides promote interspecific genetic isolation in Arabidopsis. Science 364, eaau9564.

9. Yuan, R.#, Lan, J., Fang, Y., Yu, H., Zhang, J., Huang, J., and Qin, G.* (2018). The Arabidopsis

USL1 controls multiple aspects of development by affecting late endosome morphology. New Phytol. 219,

1388–1405.

10. Cheng, S.#, Gutmann, B.#, Zhong, X.#, Ye, Y., Fisher, M.F., Bai, F., Castleden, I., Song, Y., Song,

B., Huang, J., Liu, X., Xu, X., Lim, B. L., Bond, C.S.*, Yiu, S.M.*, Small, I.* (2016). Redefining the

structural motifs that determine RNA binding and RNA editing by pentatricopeptide repeat proteins in land

plants. Plant J. 85, 532-547.

姓名

黄佳颖

性别

女

电话

邮箱

13011277622@163.com

南山学者类别

全职引进

南山学者层次

优秀人才

所在二级单位

生科院

学科分类

生物学

科研领域

基因编辑新工具开发、大数据挖掘、不同应用场景

2011-2015 华南师范大学生命科学学院, 生命科学勷勤创新班, 理学学士

2014-2015 深圳华大基因创新班, 联合培养学生

2015-2021

北京大学生命科学学院

生物技术

理学博士

2019-2020

美国罗格斯新泽西州立大学

国家公派联培博士研究生

2021-2023 中国科学院遗传与发育生物学研究所, 博士后

2023-至今广州医科大学生命科学学院，教授

个人简介

工作经历

期刊论文

教育经历