涂兆伟,研究员,广州医科大学第四层次南山人才,博士研究生导师。现就职于广州医科大学附
属第三医院妇产科研究所,主要研究方向为母胎互作与妊娠疾病发生,包括胚胎植入过程的分子调控
机制、胎盘发生和滋养层细胞分化调节机制以及复发性流产、子痫等妊娠疾病发病机理等。截至目前,
以 第 一 或 通 讯 作 者 发 表 Blood 、 Advanced Science 、 PNAS 、 Cell Death &Differ 、 Cell Reports 、
Communications Biology
、
Frontiers in Endocrinology
、
Current Opinions in Hematology
、
Int J Dev Biol
等
杂志
10
余篇,并参与发表
PNAS
、
Cell Reports
、
eLife
、
Cell Discovery
、
Human Reproduction
、
Biol Reprod
等 SCI 论文 10 余篇。主持过国家自然科学青年基金、国家自然科学面上项目、广州市市校企联合项目
和美国 CancerFree KIDs 基金,并参与了科技部重点研发项目及多项国家自然科学基金重点、重大项目。
曾获得全国妇幼健康科学技术自然科学一等奖(2021 年,7/15)。
1. TU Z, WANG C, DAVIS A K, et al. The chromatin remodeler CHD8 governs hematopoietic
stem/progenitor survival by regulating ATM-mediated P53 protein stability [J]. Blood, 2021, 138(3): 221-33.
2. TU Z, FAN C, DAVIS A K, et al. Autism-associated chromatin remodeler CHD8 regulates
erythroblast cytokinesis and fine-tunes the balance of Rho GTPase signaling [J]. Cell Rep, 2022, 40(2):
111072.
3. HUANG L, TU Z, WEI L, et al. Generating Functional Multicellular Organoids from Human
Placenta Villi [J]. Adv Sci (Weinh), 2023: e2301565.
4. LIANG Y, LAI S, HUANG L, et al. JAZF1 safeguards human endometrial stromal cells survival and
decidualization by repressing the transcription of G0S2 [J]. Commun Biol, 2023, 6(1): 568.
5. WANG L, TU Z, LIU C, et al. Dual roles of TRF1 in tethering telomeres to the nuclear envelope and
protecting them from fusion during meiosis [J]. Cell Death Differ, 2018, 25(6): 1174-88.
6. TU Z, BAYAZIT M B, LIU H, et al. Speedy A-Cdk2 binding mediates initial telomere-nuclear
envelope attachment during meiotic prophase I independent of Cdk2 activation [J]. Proc Natl Acad Sci U S
A, 2017, 114(3): 592-7.
7. TU Z, WANG Q, CUI T, et al. Uterine RAC1 via Pak1-ERM signaling directs normal luminal
epithelial integrity conducive to on-time embryo implantation in mice [J]. Cell Death Differ, 2016, 23(1):
169-81.
8. BI S, TU Z, CHEN D, et al. Histone modifications in embryo implantation and placentation: insights
from mouse models [J]. Front Endocrinol (Lausanne), 2023, 14: 1229862.
9. TU Z, ZHENG Y. Role of ATP-dependent chromatin remodelers in hematopoietic stem and
progenitor cell maintenance [J]. Curr Opin Hematol, 2022, 29(4): 174-80.
10. TU Z, RAN H, ZHANG S, et al. Molecular determinants of uterine receptivity [J]. Int J Dev
Biol, 2014, 58(2-4): 147-54.
代表性成果: