照片
陈伟钰课题组的研究聚焦于氧化应激和炎症反应，旨在探讨动脉粥样硬化及相关心血管疾病的病
理机制和治疗方法。陈伟钰 PI 既往的研究创新性地证实了内源性抗氧化剂胆红素有效防治心血管及相
关代谢疾病的作用及机制。目前课题组主要关注胆红素、维生素 C、辅酶 Q 等内源抗氧化物对血管疾
病的治疗作用及机制研究，同时也关注抗病毒药物的血管毒性及机制研究。
本课题组为青年学者提供良好的科研环境和学术氛围、完善的科研训练体系，齐备的科研仪器配
置，稳定充足的经费支持, 国内外知名团队合作平台。 课题组非常重视细节的累积，对科学实事求
是精神的坚持，通过对实验记录、课题进展、会议记录实施电子化存档透明管理，将细节与坚持融入
在每日的实验与团队工作当中。在此基础上，课题组鼓励青年学者追求独创性和批判性思维，促进跨
团队，跨领域，跨国界交流，支持个人事业的发展，不断完善推进心血管疾病理论和应用研究的发展。
陈伟钰教授于 2019 年在 The University of New South Wales (澳大利亚新南威尔士大学) 获得博士
学位，主要研究胆红素对心血管及代谢系统的保护作用及机制，为抗氧化剂治疗动脉粥样硬化、胰岛
素耐受、非酒精性脂肪肝提供了重要的医学研究基础。
2019
至
2023
年，他先后在
Victor Chang Cardiac
Research Institute (澳洲张任谦心血管研究所) 和 The Heart Research Institute (澳洲心脏研究所)，The
University of Sydney (悉尼大学) 从事研究工作，聚焦于不稳定性动脉粥样斑块病理机制以及髓过氧化
物酶
MPO
抑制剂逆转不稳定斑块的作用机制。
2023
年以广州医科大学南山学者第三层次人才项目加
入广州医科大学附属第二医院广州心血管疾病研究所。陈伟钰教授曾获国际自由基医学生物协会
(Society for Free Radical Research International) 青 年 研 究 奖 ， The Gordon Research Conference on
Chemistry and Biology of Tetrapyrroles 会议奖，The Australian Vascular Biology Society 青年研究奖。共
发表学术论文
26
篇，研究成果以第一作者身份发表在
Circulation Research, Redox Biology, Free Radical
Biology and Medicine
等领域内顶级期刊。
1. Chen W, Tumanov S, Stanley C, Kong S, Nadel J, Vigder N, Newington D, Wang X, Dunn L, Stocker R.
Destabilization of atherosclerotic plaque by bilirubin deficiency. Circulation Research. 2023;132:812 (IF: 23.2,
JCR-Q1)
2. Chen W, Nadel, J, Tumanov S and Stocker R. Near infrared autofluorescence (NIRAF) in atherosclerotic
plaque. Int. J. Mol. Sci. 2023, 24, 10727 (IF: 6.2, JCR Q1)
3. Chen W, Tumanov S, Kong S, Cheng D, Newington D, Michaëlsson E, Bongers A, Power C, Stocker R.
Therapeutic inhibition of MPO stabilizes high risk vulnerable plaque. Redox Biology. 2022;58:102532. (IF: 10.8,
JCR Q1)
4. Vigder N, Suarna C, Corcilius L, Nadel J, Chen W, Payne R, Tumanov S, Stocker R. An improved
method for the detection of myeloperoxidase chlorinating activity in biological systems using the redox probe
hydroethidine. Free Radic Biol Med. 2023;195:23 (IF: 8.1, JCR Q1)
5. Nadel J, Tumanov S, Chen W, Kong S, Giannotti N, Sivasubramanian V, Rashid I, Ugander M, Jabbour
A, Stocker R. Intraplaque myeloperoxidase is a biomarker of unstable atheroma and adverse clinical outcomes in
human atherosclerosis. JACC Adv. 2023, 3:100310
6. Kong W, Ma J, Lin Y, Chen W. Positive association of plasma trimethylamine-N-oxide and
atherosclerosis in patient with acute coronary syndrome. Cardiovascular Therapeutics. 2022;2022:2484018.
(IF:3.0, JCR Q2)
7. Chen W, Tumanov S, Fazakerley D, Cantley J, James D, Shaik T, Dunn L, Suarna C, Stocker R. Bilirubin
deficiency renders mice susceptible to hepatic steatosis in the absence of insulin resistance. Redox Biology.
2021;47:102152. (IF: 10.8, JCR Q1)
8. Lin X, Chen W, Wei F, Eradication of potential in-transit metastasis in breast-conserving surgery. JAMA
Surgery. 2022;157:174. (IF: 16.7, JCR Q1)
9. Bortolussi G, Shi X, Bloemendaa, Banerjee B, Waart D, Baj G, Chen W, Elferink R, Beuers U, Paulusma
C, Stocker R, Muro A, Bosma P. Genetic deletion of biliverdin reductase A prevents lethal neonatal
hyperbilirubinemia in Ugt1
–/–
mice. Antioxidants (Basel). 2021; 10: 2029. (IF: 7.7, JCR Q1)
10. Dunn L*, Kong S*, Tumanov S, Chen W, Cantley J, Ayer A, Maghzal G, Midwinter R, Chan K, Ng
M, Stocker R. Heme oxygenase-1 protects against ischemia-mediated injury via stabilization of hypoxia-inducible
factor-1
, Arterioscler Thromb Vasc Biol. 2021;41:317. (IF: 10.5, JCR Q1)
姓名
陈伟钰
性别
男
电话
15017588817
邮箱
wychen@gzhmu.edu.cn
南山学者类别
自然科学类
南山学者层次
优秀人才
所在二级单位
附属第二医院
学科分类
基础医学血管
科研领域
心血管疾病、动脉粥样硬化、氧化应激、炎症反应、胆红素
2023 年至今，教授，广州医科大学附属第二医院
2020-2023 年，博士后研究员，The Heart Research Institute, The University of Sydney, Australia
2019-2020
年，博士后研究员，
The Victor Chang Cardiac Research Institute, University of New South
Wales, Australia
个人简介
工作经历
期刊论文
教育经历
11. Lin X*, Chen W*, Wei F, Xie X. TV-circRGPD6 Nanoparticle Suppresses Breast Cancer Stem
Cell-Mediated Metastasis via the miR-26b/YAF2 Axis. Mol Ther. 2020; S1525: 30462. (IF: 12.9, JCR Q1)
12. Wei F*. Chen W*, Lin X. A clinical rule for the difficulty prediction on scalp intravenous access in
infants (SIAI) from emergency room. Sci Rep. 2020; 10: 6624. (IF: 5.0, JCR Q2)
13. Wei F*, Chen W*, Lin X. HIFU ablation as a therapy for breast tumor: A meta-analysis of 23
prospective feasibility studies. Breast J. 2020; 26: 1478. (IF: 2.3, JCR Q3)
14. Wei F*, Chen W*, Lin X. Efficacy and safety of adjuvant endocrine therapy in premenopausal
patients with early-stage hormone receptor-positive breast cancer: A meta-analysis of randomized controlled trials.
Breast J. 2019; 25: 1297. (IF: 2.3, JCR Q3)
15. Chen W and Stocker R. Absence of bilirubin increases oxidative stress in vivo. Atlas of Science.
2018;
16. Chen W, Maghzal G, Ayer A, Suarna C, Dunn L, Stocker R. Absence of the Bvra gene is associated
with increased endogenous oxidative stress. Free Radic Biol Med. 2018; 115: 156. (IF: 8.1, JCR Q1)
17. Li X*, Chen W*, Li P, Wei J, Cheng Y, Liu P, Yan Q, Xu X, Cui Y, Gu Z, Simoncini T, Fu X.
Follicular stimulating hormone accelerates atherogenesis by increasing endothelial VCAM-1 expression.
Theranostics. 2017; 7: 4671. (IF: 11.6, JCR Q1)
18. Lin X*, Chen W*, Wei F, Zhou B, Hung M, Xie X. Nanoparticle delivery of miR-34a eradicates
long-term-cultured breast cancer stem cells via targeting C22ORF28 Directly. Theranostics. 2017; 7: 4805. (IF:
11.6, JCR Q1)
19. Lin X*, Chen W*, Wei F, Zhou BP, Hung MC, Xie X. POMC maintains tumor-initiating properties
of tumor tissue-derived long-term-cultured breast cancer stem cells. Int J Cancer. 2017; 140: 2517. (IF: 7.4, JCR
Q1)
20. Li P, Wei J, Li X, Cheng Y, Chen W, Cui Y, Simoncini T, Gu Z, Yang J, Fu X. 17β-estradiol enhances
vascular endothelial Ets-1/miR-126-3p expression: the possible mechanism for attenuation of atherosclerosis. J
Clin Endocrinol Metab. 2017; 102: 594. (IF: 6.1, JCR Q2)
21. Chen W, Cui Y, Li P, Simoncini T, Zhang Y, Fu X. 2-methoxyestradiol induces vasodilation by
stimulating NO release via PPARγ/PI3K/Akt pathway. PLoS One. 2015; 10: e0118902. (IF: 3.8, JCR Q2)
22. Lin X*, Chen W*, Wei F, Ying M, Wei W, Xie X. Night-shift work increases morbidity of breast
cancer and all-cause mortality: a meta-analysis of 16 prospective cohort studies. Sleep Med. 2015; 16: 1381. (IF:
4.8, JCR Q2)
23. Lin X, Li J, Chen W, Wei F, Ying M, Wei W, Xie X. Diabetes and risk of anastomotic leakage after
gastrointestinal surgery. J Surg Res. 2015; 196: 294. (IF: 2.4, JCR Q2)
24. Chen W, Cheng Y, Li P, Fu X. The mechanistic exploration on the role of GPR30 in
estrogen-promoted breast cancer cell migration and invasion. Anat Res. 2015; 37: 93.
25. Fu X, Huang X, Li P, Chen W, Xia M. 7-Ketocholesterol inhibits isocitrate dehydrogenase 2
expression and impairs endothelial function via microRNA-144. Free Radic Biol Med. 2014; 71: 1. (IF: 8.1, JCR
Q1)
26. Li P, Chen W, Cheng Y, Fu X. 17β-estradiol inhibits the expression of VCAM-1 in endothelial cell
via microRNA-126. Anat Res. 2014; 36: 128.
*Co-first author, impact factor refers to 2023
1.青年研究奖, The Australian Vascular Biology Society, 2021
2.最佳演讲奖, The Society for Free Radical Research (Australasia+ Japan) Conference, 2019
3.会议奖, The Gordon Research Conference on Chemistry and Biology of Tetrapyrroles, 2018
4.青年研究奖, The Society for Free Radical Research (International) Conference, 2018
1.2024.1-2027.1, 国家自然科学基金青年项目：抗病毒药物的血管毒性及机制研究，项目负责人
2.2023.6-2028.6, 广州医科大学南山学者科研启动项目：氧化应激与动脉粥样硬化，项目负责人
科研项目
科研奖项