本科毕业于中山大学医学院法医系,推免直博进入中山大学生命科学学院直接攻读生物信息学博
士学位,在中山大学吴仲义教授的指导下将群体遗传学的理论模型应用在肿瘤演化的研究中,通过应
用超显微解剖技术提取肿瘤及肠道类器官组织样本 DNA,再通过测序等方法构建体细胞的超微演化及
转移模型。取得博士学位后申请进入英国癌症研究中心从事博士后工作,主要研究内容为分析结直肠
癌的基因组、转录组以及甲基化多组学突变数据,探索肠癌的发病分子机理和发展及演化规律。现为
“南山学者” 高层次骨干 人才,相关成 果发表于
National Science Review
、
Molecular Biology and
Evolution 等杂志上,主持国家自然科学青年基金一项,主要从事群体遗传学相关的研究,目前的研究
方向主要为:体细胞演化、肿瘤进化、肺泡损伤修复谱系。
(1) Bingjie Chen; Xianrui Wu; Yongsen Ruan; Yulin Zhang; Qichun Cai; Luis Zapata; Chung-I Wu;
Ping Lan; Haijun Wen ; Very large hidden genetic diversity in one single tumor – Evidence for
tumors-in-tumor, National Science Review, 2022, 9(12): nwac250 (Research Article, IF=23.178)
(2) Bingjie Chen; Zongkun Shi; Qingjian Chen; Xu Shen; Darryl Shibata; Haijun Wen; Chung-I Wu;
Tumorigenesis as the Paradigm of Quasi-neutral Molecular Evolution, Molecular Biology and Evolution,
2019, 36(7): 1430-144(Research Article, IF=11.062)
(3) Yongsen Ruan; Haiyu Wang; Bingjie Chen; Haijun Wen; Chung-I Wu ; Mutations Beget More
Mutations
—
Rapid Evolution of Mutation Rate in Response to the Risk of Runaway Accumulation,
Molecular Biology and Evolution, 2019, 37(4): 1019 (Research Article)
(4) Timon Heide; Jacob Househam; George D. Cresswell; Inmaculada Spiteri; Claire Lynn; Maximilian
Mossner; Chris Kimberley; Javier Fernandez-Mateos; Bingjie Chen; Luis Zapata; Chela James; Iros Barozzi;
Ketevan Chkhaidze; Daniel Nichol; Vinaya Srirangam Nadhamuni; Alison Berner; Melissa Schmidt; Eszter
Lakatos; Ann-Marie Baker; Helena Costa; Miriam Mitchinson; Rocco Piazza; Marnix Jansen; Giulio
Caravagna; Daniele Ramazzotti; Darryl Shibata; John Bridgewater; Manuel Rodriguez-Justo; Luca Magnani;
Trevor A. Graham; Andrea Sottoriva ; The co-evolution of the genome and epigenome in colorectal cancer,
Nature, 2022,611(7937):733-743 (Research Article)
(5) Jacob Househam; Timon Heide; George D. Cresswell; Inmaculada Spiteri; Chris Kimberley; Luis
Zapata; Claire Lynn; Chela James; Maximilian Mossner; Javier Fernandez-Mateos; Alessandro Vinceti;
Ann-Marie Baker; Calum Gabbutt; Alison Berner; Melissa Schmidt; Bingjie Chen; Eszter Lakatos; Vinaya
Srirangam Nadhamuni; Daniel Nichol; Helena Costa; Miriam Mitchinson; Daniele Ramazzotti; Benjamin
Werner; Francesco Iorio; Marnix Jansen; Giulio Caravagna; Chris P. Barnes; Darryl Shibata; John
Bridgewater; Manuel Rodriguez-Justo; Luca Magnani; Andrea Sottoriva; Trevor A. Graham ; Phenotypic
plasticity and genetic control in colorectal cancer evolution, Nature, 2022, 611(7937): 744-753 (Research
Article)