2019 年在阿姆斯特丹大学学术医学中心得博士学位，同年加入到奥胡斯大学生物医学系进行博士
后训练， 2023 年以“南山学者”加入广州医科大学生科院。主要从事病毒载体研究，基因编辑工具
的开发和优化，HIV 和遗传性疾病的基因治疗等。工作成果以第一作者发表在 Nucleic Acids Research,
Molecular Therapy, Journal of Biological Chemistry, Molecular-Therapy Nucleic Acids 等期刊上。
1. Gao Z, Ravendran S, Mikkelsen N, et al. A truncated reverse transcriptase enhances prime editing
by split AAV vectors. Molecular Therapy, 2022 (9).
2. Gao Z, van der Velden YU, Fan M, van der Linden CA, Vink M, Herrera-Carrillo E, Berkhout B.
Engineered miniature H1 promoters with dedicated RNA polymerase II or III activity. Journal Biology
Chemistry, 2021
3. Gao Z
, Fan M
, Das AT, et al. Extinction of all infectious HIV in cell culture by the
CRISPR-Cas12a system with only a single crRNA. Nucleic Acids Research, 2020(10).
4. Herrera-Carrillo E*, Gao Z*, Berkhout B. CRISPR therapy towards an HIV cure. Brief in Functional
Genomics, 2020 (3). (co-first)
5. Gao Z, Herrera-Carrillo E, Berkhout B. A single H1 promoter can drive both guide RNA and
endonuclease expression in the CRISPR-Cas9 system. Mol Ther Nucleic Acids, 2019.
6. Gao Z, Berkhout B, Herrera-Carrillo E. Boosting AgoshRNA activity by optimized 5'-terminal
nucleotide selection. RNA Biology, 2019(7).
7. Gao Z, Herrera-Carrillo E, Berkhout B. RNA polymerase II activity of type 3 Pol III promoters. Mol
Ther Nucleic Acids, 2018.
8. Gao Z, Herrera-Carrillo E, Berkhout B. Delineation of the exact transcription termination signal for
type 3 polymerase III. Mol Ther Nucleic Acids, 2018.
8. Gao Z, Herrera-Carrillo E, Berkhout B. Improvement of the CRISPR-Cpf1 system with
ribozyme-processed crRNA. RNA Biology, (12).
9. Gao Z, Harwig A, Berkhout B, Herrera-Carrillo E. Mutation of nucleotides around the +1 position of
type 3 polymerase III promoters: The effect on transcriptional activity and start site usage. Transcription,
2017(5).
10. Gao ZL, Zhou JH, Zhang J, Ding YZ, Liu YS. The silent point mutations at the cleavage site of
2A/2B have no effect on the self-cleavage activity of 2A of foot-and-mouth disease virus. Infect Genet
Evol, 2014.
CRISPR/Cpf1-based gene editing, gene activation, and base editing in hematopoietic stem cells
，丹麦
Lundbeck Foundation
基金（
R303-2018-3571
），
2019.6-2022.6
，主持，约合
240
万人民币。
姓名
高宗良
性别
男
电话
17663608885
邮箱
2023991005@gzhmu.edu.cn
南山学者类别
全职引进
南山学者层次
骨干人才
所在二级单位
生科院
学科分类
生物学
科研领域
病毒载体，基因编辑，基因治疗
2019 年-2023 年，就职于奥胡斯大学 生物医学系，博士后
个人简介
工作经历
期刊论文
科研项目
团队介绍
教育经历